Cell Lysis for Hard-to-Lyse Organisms

OmniLyse Inside is specifically engineered for reliable disruption of hard-to-lyse organisms, including fungi, yeast, gram-positive bacteria, and other structurally resilient microbial cells. These organisms often resist traditional lysis methods, leading to incomplete disruption and inconsistent downstream results.

By delivering rapid and consistent mechanical lysis, OmniLyse ensures efficient release of nucleic acids, improving the quality and reproducibility of DNA and RNA extraction workflows.

Designed for Difficult Sample Types

Standard chemical and enzymatic lysis approaches frequently struggle with tough cell walls and complex sample matrices. OmniLyse overcomes these limitations with a mechanical lysis method optimized for challenging organisms, providing uniform and reproducible results.

• Effective lysis of fungi, yeast, and gram-positive bacteria
• Consistent disruption of tough and resilient cell walls
• Improved DNA and RNA yield from difficult-to-process samples
• Rapid processing,typically seconds to minutes
• Compatible with downstream genomic and proteomic workflows

Applications in Advanced Workflows

OmniLyse Inside is widely used in workflows where conventional lysis methods fall short, including:

• Fungal DNA and RNA extraction
• Microbial diversity and microbiome studies
• Environmental and soil sample preparation
• Clinical and diagnostic pathogen detection
• Sample preparation for next-generation sequencing (NGS)

Why Mechanical Lysis Matters

For hard-to-lyse organisms, mechanical disruption provides a more reliable solution than chemical lysis alone. OmniLyse delivers consistent shear forces to break down even the most resilient cell structures, enabling dependable results across a wide range of organisms and sample types.

A Proven Solution for Challenging Samples

OmniLyse technology has been validated across a wide range of difficult organisms and complex matrices. For researchers working with fungi, spores, gram-positive bacteria, and other resistant cell types, OmniLyse provides a dependable, high-performance solution for efficient sample preparation.

Patents and Intellectual Property

OmniLyse technology and related extraction methods are protected by a robust portfolio of issued patents worldwide.

US 8,663,974 (issued Mar 4, 2014)
JP 5663311 (issued Dec 12, 2014)
JP 5711227 (issued Mar 13, 2015)
US 9,260,475 (issued Feb 16, 2016)
US 9,428,725 (issued Aug 30, 2016)
EP 2232259 (issued Oct 12, 2016)
JP 6040268 (issued Nov 11, 2016)
AU 2010266034 (issued Mar 30, 2017)
EP 2446047 (issued Oct 18, 2017)
US 9,873,860 (issued Jan 23, 2018)
HK 1171052 (issued Aug 3, 2018)
US D829,339 (issued Sep 25, 2018)
US 10,428,301 (issued Oct 1, 2019)
US 10,801,001 (issued Oct 13, 2020)
US 11,286,447 (issued Mar 29, 2022)
US 11,286,447 (issued Oct 18, 2022)
US 11,479,747 (issued Oct 25, 2022)
CA 2,711,854 (issued Mar 21, 2023)

Additional US and international patents pending.